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Table 2 Serum levels of vancomycin after spinal implant surgery (µg/ml)

From: Intra-wound versus systemic vancomycin for preventing surgical site infection induced by methicillin-resistant S. aureus after spinal implant surgery in a rat model

Group

0.5 h

2 h

4 h

CON

0

0

0

SV

10.21 ± 1.09

3.55 ± 0.36

0.45 ± 0.06

VP 0.5

1.36 ± 0.30

0.55 ± 0.06

0.42 ± 0.08

VP 1.0

2.98 ± 0.35

0.74 ± 0.07

0.50 ± 0.06

VP 2.0

5.20 ± 0.66

1.39 ± 0.15

0.75 ± 0.09

  1. CON control (no antibiotics); SV system vancomycin (88 mg/kg, intraperitoneal injection, half an hour pre-surgery); VP 0.5: intra-wound vancomycin powder, 44 mg/kg, once before the closure of incision intraoperatively; VP 1.0: intra-wound vancomycin powder, 88 mg/kg; VP 2.0: intra-wound vancomycin powder, 176 mg/kg. n = 8