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Fig. 4 | Journal of Orthopaedic Surgery and Research

Fig. 4

From: Temporal transcriptome highlights the involvement of cytokine/JAK/STAT3 signaling pathway in the osteoinduction of BMSCs

Fig. 4

GSEA pathway and DEGs profiles analysis. A GSEA analysis of the DEGs of 7, 14 and 21 days, shown by bubble plot together. (NES > 1) B GSEA analysis of the DEGs of 14 and 21 days, shown by bubble plot together. (NES < -1) C The intersection of DEGs between 7, 14 and 21 days. D PPI network for intersected DEGs between 7, 14 and 21 days. E–G Volcano plot for intersected DEGs between 7, 14 and 21 days (Red dots indicate significantly up-regulated genes. Blue dots indicate significantly down-regulated genes). H Venn diagram shows the intersection of the 231 DEGs, JAK-STAT and cytokine–cytokine receptor interaction signaling pathways related genes. I Heatmap to show the common DEGs of the Venn diagram above

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X