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Fig. 4 | Journal of Orthopaedic Surgery and Research

Fig. 4

From: Circ_0000479 promotes proliferation, invasion, migration and inflammation and inhibits apoptosis of rheumatoid arthritis fibroblast-like synoviocytes via miR-766/FKBP5 axis

Fig. 4

Circ_0000479 regulated MH7A cell progression by sponging miR-766. A The results of CCK-8 assays showed that the inhibitory effect of circ_0000479 knockdown on MH7A proliferation was abated by miR-766 inhibitor. B Flow cytometry analysis showed that circ_0000479 knockdown facilitated MH7A cell apoptosis, while miR-766 inhibitor attenuated the facilitation. C, D As demonstrated by transwell and wound-healing assays, circ_0000479 knockdown restrained the invasion and migration of MH7A cells, while miR-766 inhibition ameliorated the impacts. E circ_0000479 knockdown decreased the concentrations of TNF-α, IL-6 and IL-1β in MH7A cells, whereas miR-766 inhibition rescued the effects. Magnification 40 × for wound healing assays and 100 × for transwell assays. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X