Outcomes | No. of included studies | No. of patients | (S)MD or RR (95%CI) | Heterogeneity | Quality of evidence (GRADE) | |
---|---|---|---|---|---|---|
LB | TPAI | |||||
VAS at POD0 (Bupivacaine) | 129 | 131 | − 0.28 [− 1.16, 0.60] | I2 = 60%, P = 0.11 | Moderate2 | |
VAS at POD0 (Cocktail) | 78 | 76 | − 0.02 [− 0.51, 0.47] | I2 = 51%, P = 0.13 | Low1,2 | |
VAS at POD1 (Bupivacaine) | 346 | 345 | − 0.15 [− 0.73, 0.43] | I2 = 60%, P = 0.03 | Low1,5 | |
VAS at POD1 (Cocktail) | 231 | 228 | − 0.04 [− 0.32, 0.24] | I2 = 20%, P = 0.28 | Moderate1 | |
VAS at POD2 (Bupivacaine) | 283 | 302 | − 0.20 [− 0.62, 0.22] | I2 = 6%, P = 0.37 | Moderate1 | |
VAS at POD2 (Cocktail) | 231 | 228 | − 0.05 [− 0.26, 0.17] | I2 = 59%, P = 0.03 | Low1,5 | |
VAS at POD3 (Bupivacaine) | 213 | 202 | 0.00 [− 0.42, 0.42] | I2 = 0%, P = 0.79 | High | |
VAS at POD3 (Cocktail) | 89 | 86 | 0.07 [0.00, 0.14] | I2 = 0%, P = 0.84 | Moderate1 | |
Opioid consumption at 24 h | 229 | 222 | − 0.02 [− 0.21, 0.16] | I2 = 56%, P = 0.06 | Moderate1 | |
Opioid consumption at 48 h | 166 | 160 | − 0.22 [− 0.44, − 0.01] | I2 = 46%, P = 0.14 | Moderate1 | |
Opioid consumption at 72 h | 114 | 108 | − 0.32 [− 0.83, 0.19] | I2 = 69%, P = 0.04 | Moderate1 | |
Nausea and vomiting | 284 | 282 | 0.79 [0.53, 1.16] | I2 = 54%, P = 0.05 | High | |
Length of hospital stay | 474 | 454 | 0.07 [− 0.03, 0.17] | I2 = 29%, P = 0.20 | Moderate1 |