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Fig. 4 | Journal of Orthopaedic Surgery and Research

Fig. 4

From: Network pharmacology-based mechanism prediction and pharmacological validation of Bushenhuoxue formula attenuating postmenopausal osteoporosis in ovariectomized mice

Fig. 4

Seven overlapping target genes (red nodes) between BSHF formula and PMOP were enriched in VEGF signaling pathway. The signal transduction image from KEGG database showed that VEGF activates downstream targets including PCK, AKT, ERK, COX2, eNOS, etc., to promote vascular endothelial cell permeability, migration and proliferation for angiogenesis

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X