Diagnostic accuracy of sonication fluid cultures from prosthetic components in periprosthetic joint infection: an updated diagnostic meta-analysis

Peng, Guanrong; Liu, Qiang; Guan, Zhenhua; Liu, Min; Sun, Xiaobo; Zhu, Xingyang; Chen, Jinlun; Feng, Wenjun; Li, Jie; Zeng, Jianchun; Zhong, Zhangrong; Zeng, Yirong

doi:10.1186/s13018-023-03662-3

Journal of Orthopaedic Surgery and Research

Table 2 Data extracted for the construction of 2 × 2 table

From: Diagnostic accuracy of sonication fluid cultures from prosthetic components in periprosthetic joint infection: an updated diagnostic meta-analysis

Study (reference)	Publication year	Solution for prosthesis (amt [ml])	Culture period	Centrifugation	Vortexing	Cutoff value	Reference standard	Sen	Spe	TP	FP	FN	TN	Total (joints)
Hoekstra et al	2020	Ringer’s solution	Aerobic and anaerobic for 10 days	No	Yes	NA	ICM	0.81	0.98	70	3	17	136	226
Randau et al	2020	Sterile saline	Aerobic and anaerobic for 14 days	Yes	Yes	NA	MSIS	0.74	0.82	17	3	6	14	40
Torrens et al	2020	Sterile saline (200–400)	Aerobic and anaerobic for 14 days	No	Yes	50 CFU/ml	ICM	0.8	0.93	25	5	6	63	99
Banousi et al	2020	Ringer’s solution (50–200)	Aerobic for 7 days and anaerobic for 14 days	Yes	Yes	50 CFU/ml	IDSA	0.91	1.00	83	0	8	143	234
Akgun et al	2019	Normal saline	Aerobic and anaerobic for 14 days	No	Yes	50 CFU/ml	ICM	0.75	0.82	21	8	7	36	72
Bellova et al	2019	Ringer’s solution (400)	Aerobic for 4 days and anaerobic for 14 days	Yes	Yes	NA	ICM	0.88	0.85	128	17	17	95	257
Ueda et al	2019	Sterile saline (500)	Aerobic for 5 days and anaerobic for 10 days	Yes	Yes	0.1 CFU/ml	MSIS	0.71	1.00	12	0	5	50	67
Karbysheva et al	2019	NA	NA	NA	NA	NA	MSIS	0.79	0.99	62	3	17	249	331
Di et al	2019	NA	NA	NA	NA	NA	ICM	0.84	0.91	11	3	2	34	50
Tani et al	2018	Ringer’s solution (400)	Aerobic for 5 days and anaerobic for 7 days	Yes	Yes	50 CFU/ml	IDSA	0.77	0.98	47	1	14	52	114
Sebastian et al	2018	Normal saline(200–800)	Aerobic for 2–4 days and anaerobic for 7–14 days	Yes	Yes	20 CFU/ml	MSIS	0.93	1.00	25	0	2	13	40
Yan et al	2018	NA	Aerobic and anaerobic for 5–12 days	NA	NA	2 CFU/ml	IDSA	0.73	1.00	76	0	28	125	229
Grosso et al	2018	Ringer’s solution	Aerobic and anaerobic for 12.1 days	No	Yes	20 CFU/ml	IOF, H, M	0.56	0.93	14	2	11	26	53
Sambri et al	2018	Sterile saline	Aerobic for 7 days and anaerobic for 7–14 days	Yes	Yes	NA	MSIS	0.89	0.95	39	4	5	69	117
Prieto et al	2018	Sterile phosphate buffer(50)	Aerobic and anaerobic for 7 days	Yes	No	NA	IDSA	0.70	0.98	127	2	54	93	276
Huang et al	2018	Ringer’s solution (400)	Aerobic for 5 days and anaerobic for 14 days	Yes	Yes	NA	MSIS	0.83	0.86	44	2	9	12	67
Stylianakis et al	2018	Ringer’s solution	Aerobic for 7 days and anaerobic for 14 days	Yes	Yes	NA	IOF, H, M	0.63	0.82	17	16	10	71	114
Rothenberg et al	2017	Ringer’s solution (400)	Aerobic for 4 days and anaerobic for 14 days	Yes	Yes	50 CFU/ml	MSIS	0.90	0.93	160	24	18	301	503
Renz et al	2017	normal saline	Aerobic and anaerobic for 14 days	No	Yes	50 CFU/ml	EBJIS	0.58	1.00	45	0	33	33	111
VAN et al	2017	Ringer’s solution (500–800)	Aerobic and anaerobic for 5 days	Yes	Yes	50 CFU/ml	MSIS	0.47	0.99	35	2	40	175	252
Prieto et al	2017	Ringer’s solution (400)	Aerobic for 5 days and anaerobic for 7 days	Yes	Yes	NA	IDSA	0.71	0.96	27	2	11	48	88
Fernandez et al	2017	Ringer’s solution (400)	Aerobic for 5 days and anaerobic for 7 days	Yes	Yes	20 CFU/plate	NNIS	0.85	0.99	110	2	20	366	498
Fernandez et al	2015	Ringer’s solution (400)	Aerobic for 5 days and anaerobic for 7 days	Yes	Yes	20 CFU/plate	IOF, H, M	0.88	1.00	21	0	3	174	198
Bogut et al	2014	Ringer’s solution (400)	Aerobic and anaerobic for 14 days	Yes	Yes	NA	IOF, H	0.75	0.97	17	2	5	52	76
Ryu et al	2014	Ringer’s solution (400)	Aerobic for 2–5 days and anaerobic for 7–14 days	Yes	Yes	20 CFU/plate	IOF, H, M	0.77	1.00	23	0	7	15	45
Dapunt et al	2014	Ringer’s solution (400)	Aerobic and anaerobic for a maximum of 14 days	Yes	No	NA	NA	0.92	0.67	23	17	2	35	77
Portillo et al	2014	Thioglycolate broth (50–200)	Aerobic for 7 days and anaerobic for 14 days	No	Yes	50 CFU/ml	IOF, H, M	0.81	0.99	56	1	13	161	231
Drago et al	2013	Sterile saline	Aerobic for 24 h and anaerobic for 48 h	Yes	Yes	5 CFU/plate	IOF, H, M	0.71	0.94	30	2	12	32	76
Cazanave et al	2013	Ringer’s solution (400)	Aerobic for 2–4 days and anaerobic for 14 days	Yes	Yes	20 CFU/plate	NA	0.73	0.98	105	5	39	285	434
Janz et al	2013	Ringer’s solution	Aerobic and anaerobic for 14 days	No	Yes	NA	IOF, H	0.89	0.72	33	18	4	47	102
Janz et al	2013	Ringer’s solution	Aerobic and anaerobic for 14 days	No	Yes	5 CFU/plate	IOF, H, M	0.91	0.81	21	7	2	29	59
Portillo et al	2012	Thioglycolate broth (50–200)	Aerobic for 7 days and anaerobic for 14 days	No	Yes	50 CFU/ml	NA	0.6	0.99	21	1	14	99	135
Gomez et al	2012	Ringer’s solution (400)	Aerobic for 4 days and anaerobic for 14 days	Yes	Yes	2 CFU/ml	IOF, H	0.73	0.98	99	5	36	226	366
Portillo et al	2012	Thioglycolate broth (50–200)	Aerobic for 7 days and anaerobic for 14 days	No	Yes	50 CFU/ml	IOF, H, M	0.71	1.00	17	0	7	62	86
Vergidis et al	2011	Ringer’s solution (400)	Aerobic for 2–4 days and anaerobic for 14 days	Yes	Yes	20 CFU/plate	IOF, H, M	0.89	1.00	8	0	1	27	36
Piper et al	2009	Ringer’s solution (400)	Aerobic for 5 days and anaerobic for 7 days	Yes	Yes	20 CFU/plate	IOF, H	0.67	0.98	22	2	11	99	134
Trampuz et al	2007	Ringer’s solution (400)	Aerobic for 5 days and anaerobic for 7 days	Yes	Yes	5 CFU//plate	IOF, H	0.79	0.99	62	3	17	249	331
Trampuz et al	2006	Ringer’s solution (100)	Aerobic for 5 days and anaerobic for 7 days	No	No	NA	IOF, H	0.75	0.87	18	7	6	47	78

NA not available; CFU colony-forming units; MSIS Musculoskeletal Infection Society; ICM International Consensus Meeting; IDSA Infectious Diseases Society of America; EBJIS European Bone and Joint Infection Society; NNIS National Nosocomial Infections Surveillance; H histological examination; IOF intraoperative finding; M microbiological or laboratory examination; Sen Sensitivity; Spe Specificity; TP true positive; FP false positive; FN false negative; TN true negative

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ISSN: 1749-799X

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