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Fig. 7 | Journal of Orthopaedic Surgery and Research

Fig. 7

From: ERK-estrogen receptor α signaling plays a role in the process of bone marrow mesenchymal stem cell-derived exosomes protecting against ovariectomy-induced bone loss

Fig. 7

Effects of BMSC-Exos on the OVX-rats. A Micro-CT and 3D stereogram of the distal femur in rats. B Quantitative analysis of the bone volume/tissue volume fraction (BV/TV), trabecular thickness (Tb. Th), trabecular number (Tb. N), trabecular separation (Tb. Sp), and bone mineral density (BMD). (n = 3 for each group. *P < 0.05, **P < 0.01, and ***P < 0.001 compared to the sham group. #P < 0.05 and ##P < 0.001 compared to the OVX group.) C HE staining images of the femur in rats (TB: Trabecular bone, BM: Bone marrow). D ERα immunohistochemical staining images of the femur in rats. E Quantitative analysis of the number of ER-positive cells/bone surface (N.ERα/BS). (n = 6 for each group. **P < 0.01 and ***P < 0.001 compared to the sham group. ##, P < 0.001 compared to the OVX group.)

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X