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Fig. 6 | Journal of Orthopaedic Surgery and Research

Fig. 6

From: IL-1β contributes to the secretion of sclerostin by osteocytes and targeting sclerostin promotes spinal fusion at early stages

Fig. 6

Evaluation of phenotype validation of SOST−/− rats and assessment of spinal fusion. A BMD was measured by dual-energy X-ray absorptiometry. The total BMD (B), lumbar spine BMD (C) and femur BMD (D) in SOST−/− rats were higher than those in WT rats, respectively. E Representative two-dimensional and three-dimensional reconstructed CT images. F Fusion-mass volume. G CT fusion scores. H Manual palpation scores. I Representative images of hematoxylin and eosin staining and Masson trichrome staining in the four experimental groups four experimental groups (2-week WT rats, 2-week SOST−/−rats, 4-week WT rats and 4-week SOST−/− rats). Scale bar, 1 mm. Blue arrow: L4 transverse process. Green arrow: L5 transverse process. There were 6 male rat in each group. *p < 0.05 and **p < 0.01

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