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Fig. 1 | Journal of Orthopaedic Surgery and Research

Fig. 1

From: IL-1β contributes to the secretion of sclerostin by osteocytes and targeting sclerostin promotes spinal fusion at early stages

Fig. 1

Effects of IL-1β on the viability of Ocy454 and MC3T3-E1 cells and secretion of from Ocy454 cells. A, B Effects of exposure to different concentrations of IL-1β (0, 1, 5, 10, or 20 ng/ml) for 24 h on the secretion of sclerostin (A) and sclerostin mRNA expression levels (B) in Ocy454 cells. C Effects of exposure to IL-1β (0, 1, 5, 10, or 20 ng/ml) for 24 h on the viability of Ocy454 cells. D Effects of exposure to 10 ng/ml IL-1β for 24, 48, 72, or 96 h on the viability of MC3T3-E1 cells. The experiments in vitro were performed independently 3 times. *p < 0.05 and **p < 0.01 versus control cells (0 ng/ml IL-1β)

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