Fig. 2

Light microscopy images of the full thickness articular cartilage of the medial tibial plateau or medial femoral condyle from female or male, wild-type (tibia) or itga1-null (femur), mice (A). Sections are peroxidase stained for 3-nitrotyrosine or secondary only control. Scale bar 20 µm or 50 µm in high- or low-magnification images, respectively. Note the increased staining in tissues from male compared to female mice. Percent of chondrocytes stained positively for 3-nitrotyrosine as a function of sex (B) or genotype (C). Data points are means (N = 6 femora, n > 1000 cells) ± 95% CI