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Fig. 2 | Journal of Orthopaedic Surgery and Research

Fig. 2

From: LncRNA HOTTIP impacts the proliferation and differentiation of fibroblast-like synoviocytes in ankylosing spondylitis through the microRNA-30b-3p/PGK1 axis

Fig. 2

HOTTIP and PGK1 are up-regulated in AS, and down-regulated HOTTIP impedes the proliferation and differentiation of ASFLSs. A, B Expression levels of HOTTIP and PGK1 in AS patients. C, D Expression levels of HOTTIP and PGK1 in ASFLSs. E Proliferation rate of ASFLSs was measured through MTT assay. F The extracellular calcified nodules of ASFLSs were tested by Alizarin red staining. G, H Expression levels of HOTTIP and PGK1 in AS mice. I Contents of serum TNF-α, IL-6 and IL-β in each group. J Representative images of HE staining. K Representative images of TUNEL staining and the apoptosis rate of synoviocytes in each group. L Expression levels of Bax and Bcl-2 in synovial tissues. % P < 0.05 vs the control group, *P < 0.05 vs the blank or normal group, ^ P < 0.05 vs the si-NC group

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