Fig. 4

Effect of PIP combined with DOX on the PI3K/AKT/GSK3β signalling pathway. U2OS and 143B cells were treated with PIP, DOX, and PIP + DOX for 48 h. The protein was extracted, and the target protein expression was observed using western blot. A Relative expression of Bax, Bcl-2, and P53 in different groups. B Relative expression of AKT, p-AKT, p-PI3K, p-GSK3β. *P < 0.05, **P < 0.01