Fig. 6

Inhibition of GDF5 reversed the effect of miR-525-5p in C28/I2 cells. A: Transfection effect of transfected si-GDF5 in C28/I2 cells. B–C: Inhibition of GDF5 reversed the effect of miR-525-5p on C28/I2 cell viability. D–F: Inhibition of GDF5 reduced the effect of miR-525-5p on the expression of IL-1β, IL-6 and TNF-α in C28/I2 cells. G–K: Inhibition of GDF5 reduced the effect of miR-525-5p on C28/I2 cell apoptosis. *P < 0.05, **P < 0.01, ***P < 0.001; ^#P < 0.05, ^##P < 0.01, ^###P < 0.01