BMD change (%) | No. of groups | Participants | Evidence synthesis | I2 | P value | Egger's test | GRADE | |
---|---|---|---|---|---|---|---|---|
Abaloparatide versus Placebo | ||||||||
24 weeks | Lumbar spine | 8 | 2280 | WMD 3.64 [1.84, 5.44] | 97% | P < 0.00001* | P < 0.0001* | Very Low |
Fem neck | 4 | 1911 | WMD 1.85 [1.83, 1.87] | 0% | P < 0.00001* | P = 0.0003* | Low | |
Total hip | 8 | 2280 | WMD 1.65 [1.36, 1.93] | 21% | P < 0.00001* | P < 0.0001* | Low | |
48 weeks# | Lumbar spine | 1 | 1645 | WMD 9.32 [9.28, 9.36] | N/A | P < 0.00001* | N/A | Low |
Fem neck | 1 | 1645 | WMD 3.06 [3.04, 3.08] | N/A | P < 0.00001* | N/A | Low | |
Total hip | 1 | 1645 | WMD 3.32 [3.30, 3.34] | N/A | P < 0.00001* | N/A | Low | |
Abaloparatide versus Teriparatide | ||||||||
24 weeks | Lumbar spine | 3 | 266 | WMD -0.61 [− 2.89, 1.68] | 83% | P = 0.60 | P = 0.0007* | Very Low |
Fem neck | 3 | 266 | WMD 1.58 [0.52, 2.63] | 0% | P = 0.003* | P = 0.8685 | High | |
Total hip | 3 | 266 | WMD 1.46 [0.59, 2.32] | 0% | P = 0.0009* | P = 0.5417 | High | |
48 weeks# | Lumbar spine | 1 | 1642 | WMD 1.49 [1.45, 1.53] | N/A | P < 0.00001* | N/A | Low |
Fem neck | 1 | 1642 | WMD 1.11 [1.08, 1.14] | N/A | P < 0.00001* | N/A | Low | |
Total hip | 1 | 1642 | WMD 1.12 [1.10, 1.14] | N/A | P < 0.00001* | N/A | Low |