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Fig. 2 | Journal of Orthopaedic Surgery and Research

Fig. 2

From: The promotive role of USP1 inhibition in coordinating osteogenic differentiation and fracture healing during nonunion

Fig. 2

USP1 inhibition by ML323 promoted bone morphological changes in rats. A–D The BV/TV, Tb.N, Tb.Th and Tb.Sp of right femur were measured using micro-CT (micro-computerized tomography) in rats of fracture healing group, nonunion group and nonunion + ML323 group (nonunion rats treated with ML323) (n = 5/group). BV/TV, bone volume/total volume × 100%; Tb.N, trabecular number; Tb.Th, trabecular thickness; Tb.Sp, trabecular separation. E The micro-CT images (left) and typical morphology images of right femur (right) in rats of fracture healing group, nonunion group and nonunion + ML323 group (nonunion rats treated with ML323). ## indicates p < 0.01 in comparison with the fracture healing group; ** indicates p < 0.01 in comparison with the nonunion group

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X