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Fig. 1 | Journal of Orthopaedic Surgery and Research

Fig. 1

From: The promotive role of USP1 inhibition in coordinating osteogenic differentiation and fracture healing during nonunion

Fig. 1

High expression of USP1 in nonunion tissues of patients and rats. A Relative mRNA expression of USP1 in fracture healing (n = 9) and nonunion patients (n = 10). B Relative mRNA expression of USP1 in rats of fracture healing group, nonunion group and nonunion + ML323 group (nonunion rats treated with ML323) (n = 5/group). C & D Immunoblot and quantitative analysis for USP1 in rats of fracture healing group, nonunion group and nonunion + ML323 group (nonunion rats treated with ML323) (n = 5/group). β-actin was used as a loading control. E Representative immunohistochemical (IHC) staining images of the expression and localization of USP1 in rats of fracture healing group, nonunion group and nonunion + ML323 group (nonunion rats treated with ML323). Scale bar = 50 µm. ## indicates p < 0.01 in comparison with the fracture healing group; ** indicates p < 0.01 in comparison with the nonunion group

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