Table 1 Input parameters used in the health economic model
Parameters | Distribution | Base case | Range | References |
|---|---|---|---|---|
Annual transition probabilities | ||||
Well state | ||||
To index revision—LLIF | Beta | 0.0169 | 0.015–0.019 | [17] |
To adjacent revision—LLIF | Beta | 0.0088 | 0.008–0.010 | [18] |
To index revision—PLIF | Beta | 0.0203 | 0.018–0.022 | [20] |
To adjacent revision—PLIF | Beta | 0.0237 | 0.021–0.026 | [21] |
Complication | ||||
To index revision—LLIF | Beta | 0.0276 | 0.025–0.030 | [19] |
To index revision—PLIF | Beta | 0.0203 | 0.018–0.022 | [20] |
Index revision | ||||
To well—LLIF | Beta | 0.0979 | 0.010–0.088 | [17] |
To adjacent revision—LLIF | Beta | 0.0088 | 0.008–0.010 | [18] |
To well—PLIF | Beta | 0.0203 | 0.018–0.022 | [20] |
To adjacent revision—PLIF | Beta | 0.0237 | 0.021–0.026 | [21] |
Adjacent revision | ||||
To well—LLIF | Beta | 0.0088 | 0.008–0.010 | [18] |
To index revision—LLIF | Beta | 0.0088 | 0.008–0.010 | [18] |
To well—PLIF | Beta | 0.0237 | 0.021–0.026 | [21] |
To index revision—PLIF | Beta | 0.0203 | 0.018–0.022 | [20] |
Utilities | ||||
LLIF | ||||
Well | Beta | 0.840 | 0.756–0.924 | Primary data |
Complications | Beta | 0.770 | 0.693–0.847 | Primary data |
Index revision | Beta | 0.671 | 0.604–0.738 | Primary data |
Adjacent revision | Beta | 0.703 | 0.633–0.773 | Primary data |
PLIF | ||||
Well | Beta | 0.890 | 0.890–0.979 | Primary data |
Complications | Beta | 0.700 | 0.630–0.770 | Primary data |
Index revision | Beta | 0.646 | 0.581–0.711 | Primary data |
Adjacent revision | Beta | 0.679 | 0.680–0.747 | Primary data |
Costs of treatment | ||||
Total cost of well—LLIF | Gamma | 159 | 158–161 | Primary data |
Total cost of complication—LLIF | Gamma | 244 | 241–246 | Primary data |
Total cost of Index revision—LLIF | Gamma | 4041 | 4001–4081 | Primary data |
Total cost of adjacent revision—LLIF | Gamma | 10 353 | 10,249–10,456 | Primary data |
Total cost of well—PLIF | Gamma | 159 | 158–161 | Primary data |
Total cost of complications—PLIF | Gamma | 244 | 241–246 | Primary data |
Total cost of index revision—PLIF | Gamma | 4041 | 4001–4081 | Primary data |
Total cost of adjacent revision—PLIF | Gamma | 5464 | 5410–5519 | Primary data |
PEEK LLIF | Gamma | 1563 | 1548–1579 | Primary data |
PEEK PLIF | Gamma | 563 | 557–568 | Primary data |
BMP2 | Gamma | 3158 | 3127–3190 | Primary data |
Posterior spinal fusion (USD) | Gamma | 850 | 841–858 | Primary data |
Direct non-medication costs | ||||
Food IPD (USD/visit) | Gamma | 20 | 20–20 | Primary data |
Food OPD (USD/visit) | Gamma | 29 | 28–29 | [23] |
Transportation (USD/visit) | Gamma | 2 | 2–2 | [23] |