Fig. 2

SOCS3 is targeted by miR-218-5p. A The potential binding site of miR-218-5p at position 63–70 of SOCS3 3′UTR. B The miR-218-5p level in BMSCs after transfection of miR-218-5p inhibitor. C The luciferase reporter assay in BMSCs post-transfection of miR-218-5p inhibitor and the indicated plasmids. D The protein level of SOCS3 in BMSCs after miR-218-5p silencing was measured using western blotting. E Pearson correlation analysis of the expression relationship between miR-218-5p and SOCS3 in the bone tissues of OVX rats. **p < 0.01; ***p < 0.001