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Fig. 2 | Journal of Orthopaedic Surgery and Research

Fig. 2

From: Metformin regulates chondrocyte senescence and proliferation through microRNA-34a/SIRT1 pathway in osteoarthritis

Fig. 2

MicroRNA-34a regulated SIRT1 expression in chondrocytes. Chondrocytes were transfected with miR-34a mimics, siRNA against SIRT1 (si-SIRT1) or negative control (NC) at a working concentration of 100 nM, respectively. (a)–(b) miR-34a mimics and siRNA-SIRT1 inhibited SIRT1 expression in chondrocytes. All experiments were repeated three times. **P < 0.01

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X