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Fig. 1 | Journal of Orthopaedic Surgery and Research

Fig. 1

From: Metformin regulates chondrocyte senescence and proliferation through microRNA-34a/SIRT1 pathway in osteoarthritis

Fig. 1

Metformin regulated microRNA-34a and SIRT1 expression in chondrocytes. OA chondrocytes were treated with 1 mM metformin. Metformin downregulated expression level of microRNA-34a (a) and promoted mRNA level of SIRT1 (b) in OA chondrocytes. (c)–(h) immunofluorescence staining for SIRT1. (c) SIRT1, (d) nuclei stained with DAPI and (e) merged field for chondrocytes in control group. (f) SIRT1, (g) nuclei stained with DAPI and (h) merged field for metformin-treated chondrocytes in Met group. All experiments were repeated three times. **P < 0.01

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X