Mechanism of immune infiltration in synovial tissue of osteoarthritis: a gene expression-based study

Table 1 The topological properties of top 10 genes in the PPI network

Genes	Betweenness	Closeness	Clustering coefficient	Degree	DMNC	EPC	MCC	MNC	Regulation
VEGFA	550.5598	43.83333	0.41667	24	0.60059	15.328	1.14E + 07	22	Down
IL1B	161.13187	44.83333	0.51077	26	0.65261	16.407	1.10E + 08	26	Down
IL-6	186.54771	46.33333	0.50246	29	0.66612	17.256	1.11E + 08	29	Down
ATF3	243.9095	47.41667	0.44153	32	0.60491	18.053	1.00E + 08	32	Down
PTGS2	183.68112	44.83333	0.50462	26	0.64475	16.824	1.03E + 08	26	Down
NFKBIA	195.74041	44.83333	0.53538	26	0.68406	16.762	1.10E + 08	26	Down
DUSP1	398.4935	46.83333	0.47537	29	0.6302	16.963	1.04E + 08	29	Down
SOCS3	138.20615	42.16667	0.65714	21	0.84748	15.408	1.10E + 08	20	Down
MYC	844.59928	49	0.35985	33	0.52481	17.376	6.37E + 07	32	Down
JUN	556.47519	50.5	0.37538	37	0.56523	18.421	1.12E + 08	36	Down

DMNC, density of maximum neighborhood component; EPC, edge percolated component; MCC, maximal clique centrality; and MNC, maximum neighborhood component

ISSN: 1749-799X