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Fig. 5 | Journal of Orthopaedic Surgery and Research

Fig. 5

From: Nesfatin-1 suppresses autophagy of chondrocytes in osteoarthritis via remodeling of cytoskeleton and inhibiting RhoA/ROCK signal pathway

Fig. 5

Pre-treatment with nesfatin-1 inhibited RhoA/ROCK pathway activation in OA chondrocytes. A The expression of RhoA/ROCK downstream proteins (Cofilin-2, p-Cofilin-2, LIMK1 and p-LIMK1) in OA chondrocytes in different groups determined by western blot and quantified by ImageJ. B The activity of RhoGTPase in OA chondrocytes in different groups determined by RhoGTP ELISA kit. Data are expressed as means ± SD of 3 independent experiments. *p < 0.05, **p < 0.01, ***p < 0.01 compared with IL-1β group

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X