Table 3 Characteristics of pSS patients with or without arthritis
Variable | pSS with arthritis | pSS without arthritis | p value |
|---|---|---|---|
n = 41 | n = 327 | ||
Female (n, %) | 38(92.7) | 300(91.7) | 1.000 |
Age (≥ 65 year) (n, %) | 13(31.7) | 99(30.3) | 0.851 |
Disease duration (year) M (IQR) | 4(1–8) | 4(2–10) | 0.173 |
ESSDAI score M (IQR) | 7(4–9.5) | 4(2–10) | 0.011 |
Clinical manifestation (n, %) | |||
Dry mouth | 38(92.7) | 276(84.4) | 0.159 |
Objective | 21(91.3) | 201(91.8) | 1.000 |
Dry eye | 28(68.3) | 227(70.1) | 0.817 |
Objective | 12(85.7) | 70(82.4) | 1.000 |
Swollen parotid gland | 3(7.3) | 37(11.3) | 0.611 |
Renault phenomenon | 4(9.8) | 50(15.3) | 0.346 |
Joint pain | 36(87.8) | 126(38.5) | < 0.001 |
Lymphadenopathy | 1(2.4) | 18(5.5) | 0.644 |
Cutaneous | 3(7.3) | 15(4.6) | 0.704 |
Pulmonary | 9(22.0) | 68(21.0) | 0.887 |
Renal | 2(4.9) | 11(3.4) | 0.972 |
Muscular | 3(7.3) | 4(1.2) | 0.037 |
Peripheral nervous system | 2(4.9) | 15(4.6) | 1.000 |
Central nervous system | 0(0.0) | 1(0.3) | 1.000 |
Hematological system | 25(61.0) | 207(63.3) | 0.772 |
Laboratory data | |||
Hemoglobin (g/L), x ± s | 118 ± 17.3 | 117 ± 17.0 | 0.653 |
A/G | 1.2 ± 0.3 | 1.2 ± 0.3 | 0.233 |
Globulin (g/L), x ± s | 33.1 ± 6.3 | 33.2 ± 9.8 | 0.980 |
K+ (mmol/L), x ± s | 3.8 ± 0.3 | 3.8 ± 0.4 | 0.059 |
Uric acid (umol/L), M (IQR) | 273(209–331) | 267(230–316) | 0.881 |
TC (mmol/L), M (IQR) | 4.4(3.9–5.3) | 4.5(3.8–5.3) | 0.951 |
TG (mmol/L), M (IQR) | 1.1(0.8–1.7) | 1.2(0.9–1.7) | 0.246 |
HDL (mmol/L), M (IQR) | 1.1(0.9–1.6) | 1.2(0.9–1.4) | 0.817 |
FBG (mmol/L), x ± s | 4.8 ± 0.8 | 5.0 ± 1.0 | 0.297 |
C3 (g/L), x ± s | 1.0 ± 0.2 | 0.9 ± 0.2 | 0.187 |
C4 (g/L), x ± s | 0.2 ± 0.1 | 0.2 ± 0.1 | 0.435 |
ANA positive (n, %) | 28(68.3) | 216(66.3) | 0.795 |
Anti-SSA (n, %) | 24(58.5) | 206(63.2) | 0.563 |
Anti-SSB (n, %) | 9(22.0) | 92(28.2) | 0.398 |
Anti-CCP (n, %) | 1(2.9) | 8(3.0) | 1.000 |
Increased RF (n, %) | 14(36.8) | 69(24.0) | 0.090 |
IgA (g/L), x ± s | 2.9 ± 1.1 | 3.1 ± 2.4 | 0.540 |
IgM (g/L), x ± s | 1.3 ± 0.9 | 1.5 ± 2.0 | 0.511 |
IgG (g/L), x ± s | 16.8 ± 5.4 | 16.1 ± 6.8 | 0.573 |
IgG4 (g/L), x ± s | 0.5 ± 0.6 | 0.6 ± 1.5 | 0.956 |
Increased CRP (n, %) | 3(7.7) | 35(11.1) | 0.702 |
Increased ESR (n, %) | 12(29.3) | 99(32.5) | 0.682 |
Decreased 25-(OH)D (n, %) | 6(18.8) | 40(14.7) | 0.732 |