Fig. 7

Baicalin and si-lncRNA HOTAIR had synergistic effects on the PTEN/PI3K/AKT signaling pathway, APN, and inflammatory factors. After lncRNA HOTAIR knockdown and/or baicalin intervention, the protein expression of lncRNA HOTAIR, IL-6, and TNF-α was evaluated by RT-qPCR and ELISA (A–C). The protein expression of p-AKT/AKT, p-PI3K/PI3K, PTEN, APN, and ADIPOR1 was evaluated by Western blot assay (D–F). PC, PBMCs: OA-CHs. All results were represented as the mean ± standard deviation. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001; n = 3