Fig. 6

Activation of GPR84 restores the bone volume in cancer bone metastasis. A and B Representative TRAP stain images of tibias post-injection of cancer cells at D21 with administration of 6-OAU (A) and quantification of osteoclast number (B) (n = 6). Bar represents 50 μm. C and D Representative μCT of tibias.at 3 weeks post-injection of MC-38 cells (C) and quantification of bone mineral density (D) (n = 5). E–H Quantification of trabecular bone volume fraction (BV/TV) (E), trabecular thickness (Tb Th) (F), trabecular number (Tb. N) (G), trabecular separation (Tb Sp) (H) in (C) (n = 5). Significant differences are indicated as **p < 0.01 or ***p < 0.001