Table 3 Annotation (18DEG’s)

EPB41

Erythrocyte membrane protein band 4.1

Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction

BNIP3L

Adenovirus E1B 19 kDa protein-interacting protein 3-like

Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3

KLF1

Krueppel-like factor 1

Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis

SLC7A5

Large neutral amino acids transporter small subunit 1

The heterodimer with SLC3A2 functions as sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids, such as phenylalanine, tyrosine, L-DOPA, leucine, histidine, methionine and tryptophan

C10orf10

Protein DEPP1(Decidual protein induced by progesterone)

Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS

ASXL1

Polycomb group protein ASXL1

Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG). Acts as corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity

CD86

T-lymphocyte activation antigen CD86

Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. Also involved in the regulation of B cells function, plays a role in regulating the level of IgG1 produced

FCGR3A

Low affinity immunoglobulin gamma Fc region receptor III-A

Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG). Optimally activated upon binding of clustered antigen-IgG complexes displayed on cell surfaces, triggers lysis of antibody-coated cells, a process known as antibody-dependent cellular cytotoxicity (ADCC)

FCGR2B

Low affinity immunoglobulin gamma Fc region receptor II-b

Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions, such as phagocytosis of immune complexes and modulation of antibody production by B cells

CYBB

Cytochrome b-245 heavy chain

Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior

TLR2

Toll-like receptor 2

Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also activate immune cells and promote apoptosis in response to the lipid moiety of lipoproteins

TLR4

Toll-like receptor 4

Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response

ITGAX

Integrin alpha-X

Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell–cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis

TLR8

Toll-like receptor 8

Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially processed by RNASET2

TLR1

Toll-like receptor 1

Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides

FCGR2A

Low affinity immunoglobulin gamma Fc region receptor II-a

Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens

TYROBP

TYRO protein tyrosine kinase-binding protein

Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors. TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation. Required for the activation of myeloid cells mediated by the CLEC5A/MDL1 receptor. Associates with SIRPB1 to mediate activation of myeloid cells, such as monocytes and dendritic cells

MS4A6A

Membrane-spanning 4-domains subfamily A member 6A

May be involved in signal transduction as a component of a multimeric receptor complex