Term | Description | Count in gene set | P-value | FDR |
---|---|---|---|---|
Upregulated | ||||
None | Â | Â | Â | Â |
Downregulated | ||||
GO:0050707 | Regulation of cytokine secretion | 4 | 2.50E-08 | 3.70E-06 |
GO:0004872 | Receptor activity | 6 | 8.02E-08 | 2.08E-06 |
GO:0002755 | MyD88-dependent toll-like receptor Signaling pathway | 4 | 8.22E-07 | 6.08E-05 |
GO:0006955 | Immune response | 6 | 2.20E-06 | 9.02E-05 |
GO:0045087 | Innate immune response | 6 | 2.44E-06 | 9.02E-05 |
GO:0019864 | IgG binding | 3 | 1.73E-05 | 2.25E-04 |
GO:0042535 | Positive regulation of tumor necrosis Factor biosynthetic process | 3 | 1.75E-05 | 5.18E-04 |
GO:0006954 | Inflammatory response | 5 | 4.82E-05 | 0.001188048 |
GO:0005886 | Plasma membrane | 10 | 5.37E-05 | 0.001395196 |
GO:0002224 | Toll-like receptor signaling pathway | 3 | 1.11E-04 | 0.002350091 |
GO:0009986 | Cell surface | 5 | 2.16E-04 | 0.002100725 |
GO:0004888 | Transmembrane signaling receptor activity | 4 | 2.26E-04 | 0.001956399 |
GO:0009897 | External side of plasma membrane | 4 | 2.42E-04 | 0.002100725 |
GO:0016021 | Integral component of membrane | 10 | 3.58E-04 | 0.002326192 |
GO:0030670 | Phagocytic vesicle membrane | 3 | 5.56E-04 | 0.002892212 |
GO:0042495 | Detection of triacyl bacterial lipopeptide | 2 | 0.001190724 | 0.022028397 |
GO:0035354 | Toll-like receptor 1-Toll-like receptor 2 protein complex | 2 | 0.001206868 | 0.005229762 |
GO:0038123 | Toll-like receptor TLR1:TLR2 signaling pathway | 2 | 0.001785608 | 0.026426992 |
GO:0071727 | Cellular response to triacyl bacterial lipopeptide | 2 | 0.001785608 | 0.026426992 |
GO:0001875 | Lipopolysaccharide receptor activity | 2 | 0.002958753 | 0.019231894 |
GO:0051607 | Defense response to virus | 3 | 0.004100747 | 0.050269726 |
GO:0045359 | Positive regulation of interferon-beta biosynthetic process | 2 | 0.004161954 | 0.050269726 |
GO:0071723 | Lipopeptide binding | 2 | 0.004730221 | 0.024597147 |
GO:0050776 | Regulation of immune response | 3 | 0.004754813 | 0.050269726 |
GO:0045416 | Positive regulation of interleukin-8 biosynthetic process | 2 | 0.004755244 | 0.050269726 |
GO:0071223 | Cellular response to lipoteichoic acid | 2 | 0.005348217 | 0.052769071 |
GO:0042116 | Macrophage activation | 2 | 0.005940871 | 0.054953057 |
GO:0001774 | Microglial cell activation | 2 | 0.007125226 | 0.058585194 |
GO:0007252 | I-KappaB phosphorylation | 2 | 0.007125226 | 0.058585194 |
GO:0005887 | Integral component of plasma membrane | 5 | 0.007664838 | 0.028469399 |
GO:0051770 | Positive regulation of nitric-oxide synthase biosynthetic process | 2 | 0.007716928 | 0.060110805 |
GO:0032722 | Positive regulation of chemokine production | 2 | 0.010080561 | 0.074596148 |
GO:0042346 | Positive regulation of NF-KappaB import into nucleus | 2 | 0.012439125 | 0.087666214 |
GO:0001530 | Lipopolysaccharide binding | 2 | 0.012959674 | 0.056158585 |
GO:0032733 | Positive regulation of interleukin-10 production | 2 | 0.01361651 | 0.091601974 |
GO:0032735 | Positive regulation of interleukin-12 production | 2 | 0.014792631 | 0.094527539 |
GO:0032757 | Positive regulation of interleukin-8 production | 2 | 0.015380218 | 0.094527539 |
GO:0032728 | Positive regulation of interferon-beta production | 2 | 0.01596749 | 0.094527539 |
GO:0031226 | Intrinsic component of plasma membrane | 2 | 0.01677612 | 0.05452239 |
GO:0031663 | Lipopolysaccharide-mediated signaling pathway | 2 | 0.018899122 | 0.107579619 |
GO:0032755 | Positive regulation of interleukin-6 production | 2 | 0.026484616 | 0.141094616 |
GO:0007165 | Signal transduction | 4 | 0.027394902 | 0.141094616 |
GO:0032760 | Positive regulation of tumor necrosis factor production | 2 | 0.027646918 | 0.141094616 |
GO:0046982 | Protein heterodimerization activity | 3 | 0.029431373 | 0.109316528 |
GO:0007249 | I-KappaB kinase/NF-KappaB signaling | 2 | 0.03517149 | 0.173512682 |
GO:0071260 | Cellular response to mechanical stimulus | 2 | 0.041497457 | 0.197226716 |
GO:0050729 | Positive regulation of inflammatory response | 2 | 0.042643614 | 0.197226716 |
Pathway | ||||
hsa05152 | Tuberculosis | 7 | 5.14E-08 | 1.65E-06 |
hsa04620 | Toll-like receptor signaling pathway | 5 | 1.04E-05 | 1.67E-04 |
hsa04380 | Osteoclast differentiation | 5 | 2.41E-05 | 2.58E-04 |
hsa04145 | Phagosome | 5 | 4.12E-05 | 3.30E-04 |
hsa05140 | Leishmaniasis | 4 | 1.20E-04 | 7.68E-04 |
hsa05150 | Staphylococcus aureus infection | 3 | 0.00261438 | 0.01394336 |
hsa05323 | Rheumatoid arthritis | 3 | 0.006811405 | 0.031137854 |
hsa05162 | Measles | 3 | 0.015082804 | 0.054398017 |
hsa05322 | Systemic lupus erythematosus | 3 | 0.015299442 | 0.054398017 |