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Table 2 Enrichment Analysis (679DEG’s)

From: Screening and identification of potential key biomarkers for glucocorticoid-induced osteonecrosis of the femoral head

Term

Description

Count in gene set

P-value

FDR

Upregulated

None

    

Downregulated

GO:0050707

Regulation of cytokine secretion

4

2.50E-08

3.70E-06

GO:0004872

Receptor activity

6

8.02E-08

2.08E-06

GO:0002755

MyD88-dependent toll-like receptor Signaling pathway

4

8.22E-07

6.08E-05

GO:0006955

Immune response

6

2.20E-06

9.02E-05

GO:0045087

Innate immune response

6

2.44E-06

9.02E-05

GO:0019864

IgG binding

3

1.73E-05

2.25E-04

GO:0042535

Positive regulation of tumor necrosis Factor biosynthetic process

3

1.75E-05

5.18E-04

GO:0006954

Inflammatory response

5

4.82E-05

0.001188048

GO:0005886

Plasma membrane

10

5.37E-05

0.001395196

GO:0002224

Toll-like receptor signaling pathway

3

1.11E-04

0.002350091

GO:0009986

Cell surface

5

2.16E-04

0.002100725

GO:0004888

Transmembrane signaling receptor activity

4

2.26E-04

0.001956399

GO:0009897

External side of plasma membrane

4

2.42E-04

0.002100725

GO:0016021

Integral component of membrane

10

3.58E-04

0.002326192

GO:0030670

Phagocytic vesicle membrane

3

5.56E-04

0.002892212

GO:0042495

Detection of triacyl bacterial lipopeptide

2

0.001190724

0.022028397

GO:0035354

Toll-like receptor 1-Toll-like receptor 2 protein complex

2

0.001206868

0.005229762

GO:0038123

Toll-like receptor TLR1:TLR2 signaling pathway

2

0.001785608

0.026426992

GO:0071727

Cellular response to triacyl bacterial lipopeptide

2

0.001785608

0.026426992

GO:0001875

Lipopolysaccharide receptor activity

2

0.002958753

0.019231894

GO:0051607

Defense response to virus

3

0.004100747

0.050269726

GO:0045359

Positive regulation of interferon-beta biosynthetic process

2

0.004161954

0.050269726

GO:0071723

Lipopeptide binding

2

0.004730221

0.024597147

GO:0050776

Regulation of immune response

3

0.004754813

0.050269726

GO:0045416

Positive regulation of interleukin-8 biosynthetic process

2

0.004755244

0.050269726

GO:0071223

Cellular response to lipoteichoic acid

2

0.005348217

0.052769071

GO:0042116

Macrophage activation

2

0.005940871

0.054953057

GO:0001774

Microglial cell activation

2

0.007125226

0.058585194

GO:0007252

I-KappaB phosphorylation

2

0.007125226

0.058585194

GO:0005887

Integral component of plasma membrane

5

0.007664838

0.028469399

GO:0051770

Positive regulation of nitric-oxide synthase biosynthetic process

2

0.007716928

0.060110805

GO:0032722

Positive regulation of chemokine production

2

0.010080561

0.074596148

GO:0042346

Positive regulation of NF-KappaB import into nucleus

2

0.012439125

0.087666214

GO:0001530

Lipopolysaccharide binding

2

0.012959674

0.056158585

GO:0032733

Positive regulation of interleukin-10 production

2

0.01361651

0.091601974

GO:0032735

Positive regulation of interleukin-12 production

2

0.014792631

0.094527539

GO:0032757

Positive regulation of interleukin-8 production

2

0.015380218

0.094527539

GO:0032728

Positive regulation of interferon-beta production

2

0.01596749

0.094527539

GO:0031226

Intrinsic component of plasma membrane

2

0.01677612

0.05452239

GO:0031663

Lipopolysaccharide-mediated signaling pathway

2

0.018899122

0.107579619

GO:0032755

Positive regulation of interleukin-6 production

2

0.026484616

0.141094616

GO:0007165

Signal transduction

4

0.027394902

0.141094616

GO:0032760

Positive regulation of tumor necrosis factor production

2

0.027646918

0.141094616

GO:0046982

Protein heterodimerization activity

3

0.029431373

0.109316528

GO:0007249

I-KappaB kinase/NF-KappaB signaling

2

0.03517149

0.173512682

GO:0071260

Cellular response to mechanical stimulus

2

0.041497457

0.197226716

GO:0050729

Positive regulation of inflammatory response

2

0.042643614

0.197226716

Pathway

hsa05152

Tuberculosis

7

5.14E-08

1.65E-06

hsa04620

Toll-like receptor signaling pathway

5

1.04E-05

1.67E-04

hsa04380

Osteoclast differentiation

5

2.41E-05

2.58E-04

hsa04145

Phagosome

5

4.12E-05

3.30E-04

hsa05140

Leishmaniasis

4

1.20E-04

7.68E-04

hsa05150

Staphylococcus aureus infection

3

0.00261438

0.01394336

hsa05323

Rheumatoid arthritis

3

0.006811405

0.031137854

hsa05162

Measles

3

0.015082804

0.054398017

hsa05322

Systemic lupus erythematosus

3

0.015299442

0.054398017