Fig. 5

Overexpression of SERPINE1 affects the anti-aging effect of MYR. A qPCR was used to examine the effect of SERPINE1 overexpression. B SA-β-gal staining was performed to detect senescence levels in three groups of NPCs with 100 μM HO alone for 24 h or co-treated with 100 μM HO for 24 h and 10 μM MYR for 48 h. C Western blot was used to detect the expression levels of p21 and p16 in three groups of NPCs with 100 μM HO alone or co-treated with 100 μM HO and 10 μM MYR. D ELISA was used to detect the expression levels of IL-6 and IL-8 in three groups of NPCs with 100 μM HO alone or co-treated with 100 μM HO for 24 h and 10 μM MYR for 48 h