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Table 2 Multivariable analyses of factors associated with time to recurrent infection

From: Risk factors for recurrent infection in the surgical treatment of infected massive endoprostheses implanted for musculoskeletal tumours

Variable

Category/term

Hazard ratio (95% CI)

P value

Type surgery

Two-stage exchange (with reimplantation)

1

 < 0.001

Two-stage exchange (no reimplantation)

1.53 (0.63 – 3.71)

One-stage exchange

2.57 (0.98 – 6.72)

DAIR  with an exchange of modular components

4.14 (1.89 – 9.03)

DAIR without exchange of modular components

4.75 (2.43—9.30)

Excision arthroplasty ( +)

-

Local status

Uncompromised

1

 < 0.001

Compromised

2.26 (1.22 – 4.19)

Significantly compromised

4.41 (2.18 – 8.92)

Organisms

Coagulase-negative staphylococci

1

0.001

Staphylococcus aureus

2.55 (1.43 – 4.56)

Streptococcus spp.

1.41 (0.52 – 3.52)

Enterococcus spp.

7.31 (2.73 – 19.52)

Gram negative

1.51 (0.65 – 3.49)

Polymicrobial

1.04 (0.38 – 2.87)

No cultured organism

1.34 (0.51 – 3.52)

  1. ( +) Excluded from regression analysis as no reinfections in this category, values in bold are significant (p < 0.05), DAIR debridement antibiotics and implant retention