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Table 5 The total-score of molecular docking of 11 small molecules and IRF8

From: IRF8 and its related molecules as potential diagnostic biomarkers or therapeutic candidates and immune cell infiltration characteristics in steroid-induced osteonecrosis of the femoral head

Ligand

Target protein_PDB ID (kcal/mol)

IRF8_2dll

Estradiol

− 7.9

Genistein

− 7.9

Domperidone

− 7.8

Lovastatin

− 7.8

Myricetin

− 7.8

Fenbufen

− 7.7

Rosiglitazone

− 7.3

Sirolimus

− 7.2

Phenformin

− 7.1

Vorinostat

− 6.6

Vinblastine

− 6.2