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Table 2 The GSEA analysis of top 10 significant-enriched GO (BP, CC and MF)gene sets

From: IRF8 and its related molecules as potential diagnostic biomarkers or therapeutic candidates and immune cell infiltration characteristics in steroid-induced osteonecrosis of the femoral head

ONTOLOGY

ID

Description

Set size

Enrichment score

NES

P value

BP

GO:0051493

Regulation of cytoskeleton organization

495

0.331

1.594

0.001

BP

GO:0034655

Nucleobase-containing compound catabolic process

499

0.360

1.733

0.001

BP

GO:0044089

Positive regulation of cellular component biogenesis

499

0.318

1.530

0.001

BP

GO:0002521

Leukocyte differentiation

496

0.403

1.941

0.001

BP

GO:2000147

Positive regulation of cell motility

492

0.372

1.787

0.001

BP

GO:0036230

Granulocyte activation

485

0.532

2.551

0.001

BP

GO:1901652

Response to peptide

485

0.345

1.654

0.001

BP

GO:0032103

Positive regulation of response to external stimulus

474

0.462

2.214

0.001

BP

GO:0071900

Regulation of protein serine/threonine kinase activity

483

0.322

1.543

0.001

BP

GO:0042119

Neutrophil activation

480

0.531

2.543

0.001

CC

GO:0098552

Side of membrane

493

0.389

1.869

0.001

CC

GO:0010008

Endosome membrane

452

0.425

2.024

0.001

CC

GO:0005635

Nuclear envelope

435

0.352

1.678

0.001

CC

GO:0000785

Chromatin

454

0.316

1.504

0.001

CC

GO:0030055

Cell-substrate junction

406

0.395

1.873

0.001

CC

GO:0005925

Focal adhesion

400

0.400

1.895

0.001

CC

GO:0005774

Vacuolar membrane

386

0.434

2.053

0.001

CC

GO:0031252

Cell leading edge

389

0.354

1.677

0.001

CC

GO:0030133

Transport vesicle

369

0.309

1.458

0.001

CC

GO:0031300

intrinsic component of organelle membrane

351

0.331

1.553

0.001

MF

GO:0008047

Enzyme activator activity

473

0.326

1.562

0.001

MF

GO:0050839

Cell adhesion molecule binding

460

0.327

1.559

0.001

MF

GO:0031267

Small GTPase binding

413

0.334

1.582

0.001

MF

GO:0017016

Ras GTPase binding

399

0.330

1.565

0.001

MF

GO:0005543

Phospholipid binding

401

0.311

1.471

0.001

MF

GO:0042578

Phosphoric ester hydrolase activity

353

0.341

1.598

0.001

MF

GO:0033218

Amide binding

322

0.360

1.673

0.001

MF

GO:0045296

Cadherin binding

306

0.343

1.585

0.001

MF

GO:0140098

Catalytic activity, acting on RNA

335

0.376

1.748

0.001

MF

GO:0060589

Nucleoside-triphosphatase regulator activity

312

0.338

1.562

0.001

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X