Fig. 7

PPI network of DEGs and three cluster modules identified by MCODE. A The PPI network of DEGs was consisted of 300 nodes and 1192 edges. Each node represented one protein, while each edge represented one interaction. The color of nodes reflected the fold change, red color represented a upregulated gene, and blue color represented a downregulated gene, the darker the color indicated the greater the multiple of the fold change; the size of nodes reflected the degree value, the larger the node, the greater the degree value. B cluster 1: score 9.778, 19 nodes and 88 edges; C cluster 2: score 8.609, 24 nodes and 99 edges; D cluster 3: score 5.143, 22 nodes and 54 edges