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Table 3 The diagnostic value of tested markers in patients with infected nonunion

From: Combination of albumin-to-globulin ratio and plasma fibrinogen is a sensitive tool for preoperative screening of infected nonunion in patients undergoing reoperation after open reduction and internal fixation: a retrospective study

Variables

AUC (95% CI)

Optimal cutoff value

Sensitivity (%)

Specificity (%)

PPV (%)

NPV (%)

WBC

0.624 (0.546–0.702)

8.05 × 109/L

37.84

87.06

51.85

79.19

CRP

0.795 (0.732–0.858)

6.5 mg/L

71.62

82.09

59.55

88.71

ESR

0.731 (0.669–0.793)

11.5 mm/h

78.37

58.71

41.13

88.06

NLR

0.687 (0.609–0.765)

2.74

56.76

81.09

52.50

61.22

MLR

0.595 (0.512–0.677)

0.37

31.08

93.03

78.26

67.44

PLR

0.725 (0.653–0.797)

135.12

68.92

66.17

42.86

85.26

PC

0.702 (0.620–0.784)

294.5 × 109/L

51.35

89.05

63.33

83.26

Plasma D-dimer

0.752 (0.686–0.817)

0.92 mg/L

62.16

80.60

78.26

67.44

Plasma fibrinogen

0.805 (0.743–0.867)

3.25 mg/L

67.57

84.08

60.98

87.56

Albumin

0.797 (0.733–0.862)

40.55 g/L

71.62

74.13

50.48

87.65

Globulin

0.795 (0.729–0.862)

32.35 g/L

55.41

93.53

75.93

85.07

AGR

0.845 (0.785–0.904)

1.33

70.27

91.04

74.29

89.27

AGR + Plasma fibrinogen

0.916 (0.876–0.957)

0.89

86.49

92.54

81.01

94.90

  1. WBC white blood cell, CRP C-reactive protein, ESR erythrocyte sedimentation rate, PC platelet count, MLR monocyte-to-lymphocyte ratio, NLR neutrophil-to-lymphocyte ratio, PLR platelet-to-lymphocyte ratio, AGR albumin-to-globulin ratio, AUC areas under the curve, CI confidence interval, PPV positive predictive value, NPV negative predictive value