Fig. 2
From: ENPP1 deletion causes mouse osteoporosis via the MKK3/p38 MAPK/PCNA signaling pathway
Histological proliferation, differentiation, and apoptosis of cells in bone A Immunohistochemical expression pattern of Ki67 (nuclear proliferation-associated antigen Ki67), PCNA (proliferating cell nuclear antigen), OCN (osteocalcin), and RUNX2(Runt-related transcription factor 2) in distal femurs of 23-week-old mice (partial positive signals are marked with red arrows) (n = 3). B EdU immunostaining and (C) TUNEL of proximal tibia in 12-week-old mice (n = 3)