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Table 6 Significantly downregulated genes in both kidney and bone (DAE vs. Blank)

From: Transcriptional sequencing analysis reveals the potential use of deer antler for “tonifying the kidney and strengthening bone”

Gene name

Kidney

Bone

Blank (FPKM)

DAE (FPKM)

log2 fold change (DAE/Blank)

p value

Blank (FPKM)

DAE (FPKM)

log2 fold change (DAE/Blank)

p value

H-2 class II histocompatibility antigen gamma chain (Cd74)

1028.42

469.35

− 1.13

0

471.62

222.24

− 1.08

8.15E−222

Hemoglobin subunit beta-2 (Hbb-b1)

315.47

150.66

− 1.07

3.10E−83

15850.76

6579.9

− 1.27

0

Creatine kinase B-type (Ckb)

281.88

108.66

− 1.38

1.35E−281

288.78

95.38

− 1.59

7.78E−297

Interferon alpha-inducible protein 27-like protein 2B (Ifi27)

216.8

97.44

− 1.15

2.51E−100

383.36

44.83

− 3.09616

0

Lymphocyte antigen 6E (Ly6e)

178.88

79.78

− 1.16

9.02E−120

128.48

27.52

− 2.22

1.08E−177

Bone marrow stromal antigen 2 (Bst2)

181.81

72.31

− 1.33

4.73E−88

253.63

62.72

− 2.02

3.31E−185

Rano class II histocompatibility antigen, B alpha chain (RT1-Ba)

149.69

69.71

− 1.10

1.90E−81

84.44

41.24

− 1.03

8.49E−36

Plasmalemma vesicle-associated protein (Plvap)

153.31

48.83

− 1.65

8.91E−278

29.52

8.59

− 1.78

4.84E−50

C-X-C motif chemokine 16 (Cxcl16)

60.51

28.52

− 1.08

1.30E−51

9.02

4.21

− 1.10

9.45E−08

Galectin-1 (Lgals1)

96.93

27.58

− 1.81

2.14E−42

1.13

0.12

− 3.24

1.24E−06

Interferon alpha-inducible protein 27-like protein 2B (Ifi27l2b)

63.39

27.41

− 1.20

1.62E−13

345.69

62.49

− 2.47

7.85E−157

Receptor activity-modifying protein 3 (Ramp3)

46.4

22.57

− 1.03

3.65E−26

32.75

12.51

− 1.39

2.30E−24

H-2 class I histocompatibility antigen, D-37 alpha chain (RT1-S3)

49.85

22.05

− 1.18

1.15E−76

87.38

41.29

− 1.08

2.78E−95

Neuronal regeneration-related protein (Nrep)

66.99

21.67

− 1.62

3.00E−77

21.61

10.29

− 1.07

3.07E−27

Endoglin (Eng)

43.95

21.03

− 1.06

4.10E−63

26.06

10.3

− 1.34

2.26E−44

Allograft inflammatory factor 1 (Aif1)

45.51

18.3

− 1.31

6.47E−19

2.38

0.75

− 1.67

4.69E−07

Complement C1q subcomponent subunit C (C1qc)

75.83

18.12

− 2.06

9.64E−95

207.25

82.69

− 1.32

6.67E−115

Complement C1q subcomponent subunit A (C1qa)

78.49

16.97

− 2.20

1.28E−102

315.83

104.33

− 1.60

4.19E−220

Transgelin (Tagln)

50.25

16.33

− 1.62

2.11E−49

24.15

11.6

− 1.06

1.51E−11

Fatty acid-binding protein, adipocyte (Fabp4)

82.44

15.78

− 2.38

1.02E−61

638.72

107.35

− 2.57

0

Interferon regulatory factor 7 (Irf7)

51.97

15.46

− 1.74

5.78E−108

333.62

22.01

− 3.92

0

Pleckstrin homology-like domain family A member 3 (Phlda3)

23.43

9.9

− 1.24

2.58E−22

23.62

4.58

− 2.37

23.62

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 (Smarcd3)

19.34

9.5

− 1.02

8.82E−17

3.31

1.15

− 1.52

8.31E−06

Complement C1q subcomponent subunit B (C1qb)

40.68

8.16

− 2.31

3.25E−64

120.82

49.9

− 1.28

5.64E−69

Ubiquitin-like protein ISG15 (Isg15)

24.08

7.8

− 1.62

1.37E−13

119.68

8.74

− 3.78

2.60E−133

Carbonic anhydrase 3 (Car3)

 

31.72

6.61

−2.26

1.65E-74

12.26

4.98

−1.30

MARCKS-related protein (Marcksl1)

15.45

6.51

− 1.24

1.29E−15

37.21

17.85

− 1.06

3.34E−23

Low affinity immunoglobulin gamma Fc region receptor IV (Fcgr3a)

12.21

5.67

− 1.10

2.84E−08

24.25

5.73

− 2.08

1.23E−29

T-cell surface glycoprotein CD4 (Cd4)

14.03

5.66

− 1.30

2.06E−17

37.75

14.18

− 1.41

8.04E−41

H-2 class I histocompatibility antigen, D-D alpha chain (RT1-N3)

17.65

5.24

− 1.75

6.31E−34

26.14

11.41

− 1.20

1.18E−23

Lysyl oxidase homolog 1 (Loxl1)

12.45

5.2

− 1.25

6.80E−21

16.47

7.04

− 1.23

1.29E−21

RT1 class I histocompatibility antigen, AA alpha chain (RT1-CE12)

10.25

5.03

− 1.02

3.98E−06

13.75

5.37

− 1.36

9.24E−10

Thyroid hormone-inducible hepatic protein (Thrsp)

26.19

4.86

− 2.42

2.38E−51

79.26

6.03

− 3.72

9.04E−189

Reticulocalbin-3 (Rcn3)

9.52

4.41

− 1.11

3.87E−08

55.94

19.44

− 1.52

3.49E−54

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 (Gngt2)

11.18

4.14

− 1.43

2.25E−05

61.97

19.47

− 1.67

8.62E−26

Complement factor D (Cfd)

21.54

4.12

− 2.38

7.85E−26

13.39

5.08

− 1.40

4.01E−05