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Fig. 5 | Journal of Orthopaedic Surgery and Research

Fig. 5

From: Resveratrol protection against IL-1β-induced chondrocyte damage via the SIRT1/FOXO1 signaling pathway

Fig. 5

Effect of RES on IL-1β-induced apoptosis levels in chondrocytes. A Western blot analysis shows the expression of BCL-2, BAX, caspase-3, genes associated with chondrocyte apoptosis. B The relative expression of BCL-2, BAX, and caspase-3 was quantified via normalization to GAPDH. ae Correspond to control, IL-1β, IL-1β + RES, IL-1β + RES + AS, and IL-1β + RES + EX-527, respectively. CE Levels of caspase-3, BAX, and BCL-2 in chondrocytes were quantified using quantitative real-time PCR. H Detection of chondrocyte proliferation in each group using CCK-8. F, G Detection of chondrocyte proliferation in each group using TUNEL. All data are presented as the mean ± SEM (n = 3), *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001

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