Fig. 7From: Circ_0136666 aggravates osteosarcoma development through mediating miR-1244/CEP55 axisCirc_0136666 silencing notably suppresses tumor growth in vivo. A Xenograft tumors were formed through subcutaneously injecting 5 × 106 U2OS cells into the mice, and tumor volume was evaluated every week as width2 × length × 0.5. B Tumors resected from nude mice after 5-week injection were weighed. C The protein level of Ki-67 was examined by IHC assay. D and E RT-qPCR and Western blot assay were conducted to measure the expression of circ_0136666, miR-1244 and CEP55 protein. **P < 0.01, ***P < 0.001Back to article page