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Fig. 3 | Journal of Orthopaedic Surgery and Research

Fig. 3

From: Circ_0051079 functions as an oncogenic regulator in osteosarcoma by leading to MAFB expression upregulation by competitively interacting with miR-1286

Fig. 3

Circ_0051079 exhibited the sponge function of miR-1286. A Starbase3.0 was used for bioinformatics analysis between circ_0051079 and miR-1286 sequences. B The miR-1286 level was examined using RT-qPCR in SaoS-2 and U2OS cells transfected with miR-NC or miR-1286. C, D Circ_0051079 and miR-1286 target binding analysis was performed using dual-luciferase reporter assay. E RT-qPCR was applied to measure miR-1286 expression after transfection with si-NC or si-circ_0051079. F, G Expression quantification of miR-1286 was conducted via RT-qPCR in OS samples (F) and SaoS-2/U2OS cells (G). H Linear association between circ_0051079 and miR-1286 was analyzed through Pearson’s correlation coefficient. *P < 0.05

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