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Table 1 Demographic data of the included studies

From: Platelet-rich plasma use in meniscus repair treatment: a systematic review and meta-analysis of clinical studies

References

Country

Design/level of evidence

Sample size (PRP/control)

BMI

Mean age (years)

Gender (M/F)

PRP preparation

PRP injection protocol

PRP/PRFM

LR/LP

Follow-up (months)

Yang et al. [26]

China

Retrospective comparative trial/III

61 (30/31)

25.2

36.4

44/17

Regen Kit

Multiple intra-articular injection after surgery

PRP

NR

33

Bailey et al. [25]

America

Retrospective matched case–control study/III

324 (162/162)

25.6

22.2

192/132

Angel double-spin, concentrated PRP system

Intraoperative administration

PRP

LR

24

Kaminski et al. [34]

Poland

Prospective, randomized, placebo-controlled, double-blind study/I

72 (42/30)

27.4

44.8

41/31

Activated using autologous thrombin

Minimally invasive intrameniscal application (6–8 mL)

PRP

LR

23

Everhart et al. [33]

America

Cohort study/III

550 (203/347)

27.6

28.8

348/202

GPS III system and Angel system

Introduced into the joint before closure (5 mL)

PRP

LR

36

Dai et al. [19]

China

Retrospective cohort/III

29 (14/15)

NR

31.3

11/18

Sodium citrate as anticoagulant

Injected on the repaired site under arthroscope (4 mL)

PRP

LR

20.6

Kemmochi et al. [32]

Japan

Prospective, interventional, non-randomized trial/II

22 (17/5)

NR

29.8

12/10

PRF box

Inserted into the cleft of the injured meniscus (2.4 cm3)

PRFM

LR

6

Kaminski et al. [31]

Poland

Prospective, randomized, double-blind, placebo-controlled, parallel-arm study/I

37 (19/18)

NR

28.1

30/7

ELISA and blood analyzer; Activated using autologous thrombin

Injected into meniscal repair site (8 mL)

PRP

LR

54

Pujol et al. [30]

France

Retrospective cohort/III

34 (17/17)

NR

30.3

24/10

GPS III system

In situ injection after mini-arthrotomy (5 mL)

PRP

LR

32.2

Griffin et al. [20]

America

Retrospective cohort /III

35 (15/20)

25

31.0

28/7

Cascade Platelet-Rich Fibrin Matrix

Sutured into meniscal repair site

PRFM

NR

48

  1. PRP Platelet-rich plasma; PRFM Platelet-rich fibrin matrix; LP Leukocyte-poor; LR Leukocyte-rich; BMI Body mass index; ELISA Enzyme linked immunosorbent assay; NR Not report