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Table 4 Genes enriched in GO terms and KEGG pathways related to osteoporosis and diabetes

From: A gene expression profile for the lower osteogenic potent of bone-derived MSCs from osteoporosis with T2DM and the potential mechanism

Key words

GO/KEGG ID

GO term/KEGG pathway

Gene UP

Gene DOWN

Enrich factor

Osteo-

GO:0045670

Regulation of osteoclast differentiation

RASSF2, TYROBP, TREM2, PRXL2A

GPR68

3.96

GO:0030316

Osteoclast differentiation

TYROBP, RASSF2, TREM2, PRXL2A, FCER1G

GPR68

3.07

GO:0045667

Regulation of osteoblast differentiation

RANBP3L, RASSF2, SFRP2

BMP2, SMAD6, VEGFC

2.90

GO:0001649

Osteoblast differentiation

RANBP3L, VCAN, SFRP2, RASSF2

CYP24A1, MYOC, BMP2, SMAD6, VEGFC, CBFB

2.70

hsa04380

Osteoclast differentiation

NCF2, ACP5, FCGR1A, TREM2, SPI1, SYK, TYROBP

JUN, FOSL1

4.19

Bone

GO:0046849

Bone remodeling

ACP5, SYK, RASSF2

GDF5, SYT7

3.23

GO:0060348

Bone development

RANBP3L, ACP5, INSIG1, SFRP2, TYROBP

MYOC, BMP2, GPR68, SCARA3, DCHS1, RARG

2.97

GO:0060349

Bone morphogenesis

SFRP2, ACP5, INSIG1

RARG, SCARA3

2.75

GO:0,030,282

Bone mineralization

FGR, GPM6B

OSR1, BMP2

2.09

Diabet-

hsa04940

Type I diabetes mellitus

–

HLA-B, IL12A, HLA-DRB5, HLA-DRB1

5.55

hsa04933

AGE-RAGE signaling pathway in diabetic complications

AGT, CYBB

JUN, EGR1, VEGFC, PLCD3, CCND1

4.18

hsa04930

Type II diabetes mellitus

–

IRS2

1.30

Insulin

GO:0005520

Insulin-like growth factor binding

HTRA3, IGFBP2

IGFBP6, ESM1

8.45

GO:0061178

Regulation of insulin secretion involved in cellular response to glucose stimulus

FKBP1B, HMGCR

ADCY8, NR1D1, GPR68, HLA-DRB1

6.34

GO:0035773

Insulin secretion involved in cellular response to glucose stimulus

FKBP1B, HMGCR

NR1D1, HLA-DRB1, ADCY8, GPR68

5.51

GO:0032024

Positive regulation of insulin secretion

–

HLA-DRB1, IRS2, ADCY8, GPR68

3.21

GO:0050796

Regulation of insulin secretion

HMGCR, FKBP1B

NR1D1, IRS2, ADCY8, SYT7, GPR68, HLA-DRB1

2.53

GO:0030073

Insulin secretion

FKBP1B, HMGCR

GPR68, SYT7, ADCY8, HLA-DRB1, IRS2, NR1D1

2.17

GO:0032868

Response to insulin

PLN, FABP3, AGT, IGFBP2, FADS1, RARRES2

IRS2, EGR1, RAB8A, ADM

2.08

GO:0032869

Cellular response to insulin stimulus

RARRES2, AGT

RAB8A, IRS2

1.05

hsa04910

Insulin signaling pathway

FBP1

EIF4E, PTPRF, IRS2

1.74

hsa04931

Insulin resistance

AGT

PTPRF, IRS2

1.66

hsa04911

Insulin secretion

–

ADCY8, ADCY4

1.39

Glu-

GO:0061178

Regulation of insulin secretion involved in cellular response to glucose stimulus

FKBP1B, HMGCR

ADCY8, NR1D1, GPR68, HLA-DRB1

6.34

GO:0035773

Insulin secretion involved in cellular response to glucose stimulus

FKBP1B, HMGCR

NR1D1, HLA-DRB1, ADCY8, GPR68

5.51

GO:0071333

Cellular response to glucose stimulus

FKBP1B, HMGCR

GPR68, ADCY8, HLA-DRB1, IRS2, NR1D1

2.98

GO:0001678

Cellular glucose homeostasis

FKBP1B, HMGCR

ADCY8, GPR68, HLA-DRB1, NR1D1, IRS2

2.61

GO:0009749

Response to glucose

FKBP1B, HMGCR

EGR1, ADCY8, GPR68, HLA-DRB1, NR1D1, IRS2

2.36

GO:0042593

Glucose homeostasis

FKBP1B, HMGCR

GPR68, NR1D1, HLA-DRB1, ADCY8, IRS2

1.66

GO:0006006

Glucose metabolic process

FBP1, SDS

ATF3, IRS2

1.15

hsa04922

Glucagon signaling pathway

FBP1

–

0.56

Glyco-

hsa00010

Glycolysis/gluconeogenesis

FBP1

–

0.89

  1. Italic genes: transcription factors; bold genes: target genes of transcription factors