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Table 4 Genes enriched in GO terms and KEGG pathways related to osteoporosis and diabetes

From: A gene expression profile for the lower osteogenic potent of bone-derived MSCs from osteoporosis with T2DM and the potential mechanism

Key words GO/KEGG ID GO term/KEGG pathway Gene UP Gene DOWN Enrich factor
Osteo- GO:0045670 Regulation of osteoclast differentiation RASSF2, TYROBP, TREM2, PRXL2A GPR68 3.96
GO:0030316 Osteoclast differentiation TYROBP, RASSF2, TREM2, PRXL2A, FCER1G GPR68 3.07
GO:0045667 Regulation of osteoblast differentiation RANBP3L, RASSF2, SFRP2 BMP2, SMAD6, VEGFC 2.90
GO:0001649 Osteoblast differentiation RANBP3L, VCAN, SFRP2, RASSF2 CYP24A1, MYOC, BMP2, SMAD6, VEGFC, CBFB 2.70
hsa04380 Osteoclast differentiation NCF2, ACP5, FCGR1A, TREM2, SPI1, SYK, TYROBP JUN, FOSL1 4.19
Bone GO:0046849 Bone remodeling ACP5, SYK, RASSF2 GDF5, SYT7 3.23
GO:0060348 Bone development RANBP3L, ACP5, INSIG1, SFRP2, TYROBP MYOC, BMP2, GPR68, SCARA3, DCHS1, RARG 2.97
GO:0060349 Bone morphogenesis SFRP2, ACP5, INSIG1 RARG, SCARA3 2.75
GO:0,030,282 Bone mineralization FGR, GPM6B OSR1, BMP2 2.09
Diabet- hsa04940 Type I diabetes mellitus HLA-B, IL12A, HLA-DRB5, HLA-DRB1 5.55
hsa04933 AGE-RAGE signaling pathway in diabetic complications AGT, CYBB JUN, EGR1, VEGFC, PLCD3, CCND1 4.18
hsa04930 Type II diabetes mellitus IRS2 1.30
Insulin GO:0005520 Insulin-like growth factor binding HTRA3, IGFBP2 IGFBP6, ESM1 8.45
GO:0061178 Regulation of insulin secretion involved in cellular response to glucose stimulus FKBP1B, HMGCR ADCY8, NR1D1, GPR68, HLA-DRB1 6.34
GO:0035773 Insulin secretion involved in cellular response to glucose stimulus FKBP1B, HMGCR NR1D1, HLA-DRB1, ADCY8, GPR68 5.51
GO:0032024 Positive regulation of insulin secretion HLA-DRB1, IRS2, ADCY8, GPR68 3.21
GO:0050796 Regulation of insulin secretion HMGCR, FKBP1B NR1D1, IRS2, ADCY8, SYT7, GPR68, HLA-DRB1 2.53
GO:0030073 Insulin secretion FKBP1B, HMGCR GPR68, SYT7, ADCY8, HLA-DRB1, IRS2, NR1D1 2.17
GO:0032868 Response to insulin PLN, FABP3, AGT, IGFBP2, FADS1, RARRES2 IRS2, EGR1, RAB8A, ADM 2.08
GO:0032869 Cellular response to insulin stimulus RARRES2, AGT RAB8A, IRS2 1.05
hsa04910 Insulin signaling pathway FBP1 EIF4E, PTPRF, IRS2 1.74
hsa04931 Insulin resistance AGT PTPRF, IRS2 1.66
hsa04911 Insulin secretion ADCY8, ADCY4 1.39
Glu- GO:0061178 Regulation of insulin secretion involved in cellular response to glucose stimulus FKBP1B, HMGCR ADCY8, NR1D1, GPR68, HLA-DRB1 6.34
GO:0035773 Insulin secretion involved in cellular response to glucose stimulus FKBP1B, HMGCR NR1D1, HLA-DRB1, ADCY8, GPR68 5.51
GO:0071333 Cellular response to glucose stimulus FKBP1B, HMGCR GPR68, ADCY8, HLA-DRB1, IRS2, NR1D1 2.98
GO:0001678 Cellular glucose homeostasis FKBP1B, HMGCR ADCY8, GPR68, HLA-DRB1, NR1D1, IRS2 2.61
GO:0009749 Response to glucose FKBP1B, HMGCR EGR1, ADCY8, GPR68, HLA-DRB1, NR1D1, IRS2 2.36
GO:0042593 Glucose homeostasis FKBP1B, HMGCR GPR68, NR1D1, HLA-DRB1, ADCY8, IRS2 1.66
GO:0006006 Glucose metabolic process FBP1, SDS ATF3, IRS2 1.15
hsa04922 Glucagon signaling pathway FBP1 0.56
Glyco- hsa00010 Glycolysis/gluconeogenesis FBP1 0.89
  1. Italic genes: transcription factors; bold genes: target genes of transcription factors