Key words | GO/KEGG ID | GO term/KEGG pathway | Gene UP | Gene DOWN | Enrich factor |
---|---|---|---|---|---|
Osteo- | GO:0045670 | Regulation of osteoclast differentiation | RASSF2, TYROBP, TREM2, PRXL2A | GPR68 | 3.96 |
GO:0030316 | Osteoclast differentiation | TYROBP, RASSF2, TREM2, PRXL2A, FCER1G | GPR68 | 3.07 | |
GO:0045667 | Regulation of osteoblast differentiation | RANBP3L, RASSF2, SFRP2 | BMP2, SMAD6, VEGFC | 2.90 | |
GO:0001649 | Osteoblast differentiation | RANBP3L, VCAN, SFRP2, RASSF2 | CYP24A1, MYOC, BMP2, SMAD6, VEGFC, CBFB | 2.70 | |
hsa04380 | Osteoclast differentiation | NCF2, ACP5, FCGR1A, TREM2, SPI1, SYK, TYROBP | JUN, FOSL1 | 4.19 | |
Bone | GO:0046849 | Bone remodeling | ACP5, SYK, RASSF2 | GDF5, SYT7 | 3.23 |
GO:0060348 | Bone development | RANBP3L, ACP5, INSIG1, SFRP2, TYROBP | MYOC, BMP2, GPR68, SCARA3, DCHS1, RARG | 2.97 | |
GO:0060349 | Bone morphogenesis | SFRP2, ACP5, INSIG1 | RARG, SCARA3 | 2.75 | |
GO:0,030,282 | Bone mineralization | FGR, GPM6B | OSR1, BMP2 | 2.09 | |
Diabet- | hsa04940 | Type I diabetes mellitus | – | HLA-B, IL12A, HLA-DRB5, HLA-DRB1 | 5.55 |
hsa04933 | AGE-RAGE signaling pathway in diabetic complications | AGT, CYBB | JUN, EGR1, VEGFC, PLCD3, CCND1 | 4.18 | |
hsa04930 | Type II diabetes mellitus | – | IRS2 | 1.30 | |
Insulin | GO:0005520 | Insulin-like growth factor binding | HTRA3, IGFBP2 | IGFBP6, ESM1 | 8.45 |
GO:0061178 | Regulation of insulin secretion involved in cellular response to glucose stimulus | FKBP1B, HMGCR | ADCY8, NR1D1, GPR68, HLA-DRB1 | 6.34 | |
GO:0035773 | Insulin secretion involved in cellular response to glucose stimulus | FKBP1B, HMGCR | NR1D1, HLA-DRB1, ADCY8, GPR68 | 5.51 | |
GO:0032024 | Positive regulation of insulin secretion | – | HLA-DRB1, IRS2, ADCY8, GPR68 | 3.21 | |
GO:0050796 | Regulation of insulin secretion | HMGCR, FKBP1B | NR1D1, IRS2, ADCY8, SYT7, GPR68, HLA-DRB1 | 2.53 | |
GO:0030073 | Insulin secretion | FKBP1B, HMGCR | GPR68, SYT7, ADCY8, HLA-DRB1, IRS2, NR1D1 | 2.17 | |
GO:0032868 | Response to insulin | PLN, FABP3, AGT, IGFBP2, FADS1, RARRES2 | IRS2, EGR1, RAB8A, ADM | 2.08 | |
GO:0032869 | Cellular response to insulin stimulus | RARRES2, AGT | RAB8A, IRS2 | 1.05 | |
hsa04910 | Insulin signaling pathway | FBP1 | EIF4E, PTPRF, IRS2 | 1.74 | |
hsa04931 | Insulin resistance | AGT | PTPRF, IRS2 | 1.66 | |
hsa04911 | Insulin secretion | – | ADCY8, ADCY4 | 1.39 | |
Glu- | GO:0061178 | Regulation of insulin secretion involved in cellular response to glucose stimulus | FKBP1B, HMGCR | ADCY8, NR1D1, GPR68, HLA-DRB1 | 6.34 |
GO:0035773 | Insulin secretion involved in cellular response to glucose stimulus | FKBP1B, HMGCR | NR1D1, HLA-DRB1, ADCY8, GPR68 | 5.51 | |
GO:0071333 | Cellular response to glucose stimulus | FKBP1B, HMGCR | GPR68, ADCY8, HLA-DRB1, IRS2, NR1D1 | 2.98 | |
GO:0001678 | Cellular glucose homeostasis | FKBP1B, HMGCR | ADCY8, GPR68, HLA-DRB1, NR1D1, IRS2 | 2.61 | |
GO:0009749 | Response to glucose | FKBP1B, HMGCR | EGR1, ADCY8, GPR68, HLA-DRB1, NR1D1, IRS2 | 2.36 | |
GO:0042593 | Glucose homeostasis | FKBP1B, HMGCR | GPR68, NR1D1, HLA-DRB1, ADCY8, IRS2 | 1.66 | |
GO:0006006 | Glucose metabolic process | FBP1, SDS | ATF3, IRS2 | 1.15 | |
hsa04922 | Glucagon signaling pathway | FBP1 | – | 0.56 | |
Glyco- | hsa00010 | Glycolysis/gluconeogenesis | FBP1 | – | 0.89 |