A gene expression profile for the lower osteogenic potent of bone-derived MSCs from osteoporosis with T2DM and the potential mechanism

Table 3 Expression changes of all transcription factors

	Gene id	TF name	Family	log2FC	log2FC abs	FC abs	p Value	Up/down
1	ENSG00000066336	SPI1	ETS	4.66	4.66	25.27	0.008	UP
2	ENSG00000146587	RBAK	zf-C2H2	4.15	4.15	17.70	0.000	UP
3	ENSG00000115956	PLEK	Others	4.02	4.02	16.20	0.015	UP
4	ENSG00000064195	DLX3	Homeobox	− 2.99	2.99	7.92	0.012	DOWN
5	ENSG00000146618	FERD3L	bHLH	− 2.67	2.67	6.38	0.049	DOWN
6	ENSG00000164379	FOXQ1	Fork_head	− 2.35	2.35	5.11	0.005	DOWN
7	ENSG00000131668	BARX1	Homeobox	− 2.16	2.16	4.47	0.001	DOWN
8	ENSG00000069011	PITX1	Homeobox	− 1.88	1.88	3.67	0.004	DOWN
9	ENSG00000168874	ATOH8	bHLH	− 1.84	1.84	3.57	0.001	DOWN
10	ENSG00000257315	ZBED6	zf-BED	1.83	1.83	3.56	0.000	UP
11	ENSG00000162772	ATF3	TF_bZIP	− 1.78	1.78	3.43	0.021	DOWN
12	ENSG00000175592	FOSL1	TF_bZIP	− 1.64	1.64	3.12	0.000	DOWN
13	ENSG00000120738	EGR1	zf-C2H2	− 1.49	1.49	2.81	0.003	DOWN
14	ENSG00000165244	ZNF367	zf-C2H2	− 1.47	1.47	2.76	0.022	DOWN
15	ENSG00000137309	HMGA1	HMGA	− 1.39	1.39	2.63	0.003	DOWN
16	ENSG00000137834	SMAD6	MH1	− 1.28	1.28	2.42	0.016	DOWN
17	ENSG00000067955	CBFB	CBF	− 1.21	1.21	2.31	0.018	DOWN
18	ENSG00000185022	MAFF	TF_bZIP	− 1.21	1.21	2.31	0.007	DOWN
19	ENSG00000172819	RARG	THR-like	− 1.18	1.18	2.27	0.009	DOWN
20	ENSG00000187079	TEAD1	TEA	1.14	1.14	2.21	0.022	UP
21	ENSG00000136826	KLF4	zf-C2H2	− 1.09	1.09	2.13	0.021	DOWN
22	ENSG00000143867	OSR1	zf-C2H2	− 1.07	1.07	2.11	0.049	DOWN
23	ENSG00000108175	ZMIZ1	zf-MIZ	− 1.05	1.05	2.07	0.038	DOWN
24	ENSG00000126368	NR1D1	THR-like	− 1.02	1.02	2.03	0.046	DOWN
25	ENSG00000251493	FOXD1	Fork_head	− 0.97	0.97	1.96	0.042	DOWN
26	ENSG00000177606	JUN	TF_bZIP	− 0.97	0.97	1.96	0.036	DOWN

ISSN: 1749-799X