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Fig. 6 | Journal of Orthopaedic Surgery and Research

Fig. 6

From: A gene expression profile for the lower osteogenic potent of bone-derived MSCs from osteoporosis with T2DM and the potential mechanism

Fig. 6

Knockdown of FOXQ1 inhibits the osteogenic differentiation of CON-BMSC. A qPCR analysis of the fold change of the top 8 TFs in T2DM-BMSC. B The expression level of FOXQ1 in another 10 specimens-derived BMSCs was detected. C qPCR and western blot were used to detect the mRNA and protein levels of FOXQ1 after CON-BMSC transfected with siRNAs. D qPCR was used to analyze the expression levels of three osteogenic markers in CON-BMSC silenced of FOXQ1. E ALP staining (left) and activity detection (right) were performed to detect the role of silencing FOXQ1 on the ALP expression level of CON-BMSC. F ARS staining was used to evaluate the role of silencing FOXQ1 on the mineralization level in CON-BMSC

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