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Fig. 4 | Journal of Orthopaedic Surgery and Research

Fig. 4

From: Metformin alleviates osteoarthritis in mice by inhibiting chondrocyte ferroptosis and improving subchondral osteosclerosis and angiogenesis

Fig. 4

Metformin alleviated chondrocyte ferroptosis in the destabilization of the medial meniscus mice model. Immunohistochemical staining of A GPX4, B SLC7A11, C p53 and D ACSL4 (scale bar, 100 µm). Arrows indicate positive cells and E GPX4, F SLC7A11, G p53 and H ACSL4-positive cell proportions. One-way ANOVA and Tukey’s multiple comparison tests were used to compare the data. **P < 0.01; ***P < 0.001

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X