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Fig. 5 | Journal of Orthopaedic Surgery and Research

Fig. 5

From: Circ-FOXM1 promotes the proliferation, migration and EMT process of osteosarcoma cells through FOXM1-mediated Wnt pathway activation

Fig. 5

Circ-FOXM1 accelerated OS progression through upregulating FOXM1 to activate Wnt signaling pathway. a qRT-PCR analysis of the overexpression efficacy of FOXM1 in U2OS cells. b Western blot assay detected the level of FOXM1, β-catenin, C-myc, MMP2, MMP9, E-cadherin and N-cadherin in different groups. c IF (bar value = 20 μm) assay detected the level and distribution of β-catenin in different groups. d, e CCK-8 and EdU (bar value = 50 μm) assays evaluated the proliferation of OS cells in different groups. f TUNEL (bar value = 50 μm) assay measured the apoptosis of OS cells in different groups. g Transwell (bar value = 50 μm) assay examined cell migration in different groups. **P < 0.01

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X