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Fig. 3 | Journal of Orthopaedic Surgery and Research

Fig. 3

From: Circ-FOXM1 promotes the proliferation, migration and EMT process of osteosarcoma cells through FOXM1-mediated Wnt pathway activation

Fig. 3

Circ-FOXM1 could regulate the expression level of FOXM1 post-transcriptionally. a From GEPIA database, we found the upregulation of FOXM1 in sarcoma (SARC) tissues. b qRT-PCR examined the relatively high expression of FOXM1 in OS cells, in comparison with normal hFOB1.19 cells. c The mRNA expression and protein level of FOXM1 were detected in cells transfected with sh-NC or sh-circ-FOXM1#1/2 through qRT-PCR and western blot analyses. d Luciferase reporter assay detected the impact of circ-FOXM1 knockdown on FOXM1 transcription. e RIP assay confirmed the coexistence of circ-FOXM1 and FOXM1 in Ago2-assembled RISCs. *P < 0.05, **P < 0.01

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X