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Table 3 Toxicity profiling of core compounds

From: Network pharmacology and molecular docking approach to elucidate the mechanisms of Liuwei Dihuang pill in diabetic osteoporosis

Property Range reference Value
Beta-sitosterol Stigmasterol Diosgenin Tetrahydroalstonine Kadsurenone
hERG blockers 1: active
0: inactive
0.049 0.012 0.029 0.911 0.055
Human hepatotoxicity 1: positive
0: negative
0.16 0.011 0.204 0.6 0.42
Drug-induced liver injury 1: high risk
0: no risk
0.203 0.055 0.057 0.07 0.09
AMES toxicity 1: positive
0: negative
0.026 0.029 0.053 0.754 0.018
Rat oral acute toxicity 1: high
0: low
0.018 0.054 0.748 0.957 0.235
Maximum recommended daily dose 1: FDAMDD (+)
0: FDAMDD (−)
0.73 0.539 0.646 0.959 0.826
Skin sensitization 1: sensitizer 0: non-sensitizer 0.133 0.025 0.241 0.098 0.211
Carcinogen city 1: carcinogen;
0: non-carcinogen
0.047 0.054 0.188 0.972 0.887
Eye corrosion 1: corrosive
0: noncorrosive
0.003 0.003 0.003 0.003 0.003
Eye irritation 1: irritant
0: nonirritant
0.01 0.01 0.009 0.013 0.012
Respiratory toxicity 1: toxicant;
0: nontoxicant
0.536 0.19 0.517 0.976 0.958