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Fig. 5 | Journal of Orthopaedic Surgery and Research

Fig. 5

From: Roxadustat promotes osteoblast differentiation and prevents estrogen deficiency-induced bone loss by stabilizing HIF-1α and activating the Wnt/β-catenin signaling pathway

Fig. 5

HIF-1α expression knockdown disrupted roxadustat-promoted increase in the protein expression of osteogenic markers in osteoblasts. The protein expression levels of HIF-1α, Runx2 and OCN at day 4 of roxadustat treatment. Data are presented as the mean ± SD of three independent experiments; **P < 0.01, compared with the siNC group; ##P < 0.01, compared with the siHIF-1α + roxadustat group. Roxadustat concentration: 5 μM

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X