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Fig. 4 | Journal of Orthopaedic Surgery and Research

Fig. 4

From: Roxadustat promotes osteoblast differentiation and prevents estrogen deficiency-induced bone loss by stabilizing HIF-1α and activating the Wnt/β-catenin signaling pathway

Fig. 4

HIF-1α expression knockdown disrupted roxadustat-promoted osteoblast differentiation and matrix mineralization. A ALP staining at day 7. B Alizarin Red S staining at day 14. Data are presented as the mean ± SD of three independent experiments; *P < 0.05, **P < 0.01, compared with the siNC group; ##P < 0.01, compared with the siHIF-1α + roxadustat group. Roxadustat concentration: 5 μM

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