Fig. 4From: Roxadustat promotes osteoblast differentiation and prevents estrogen deficiency-induced bone loss by stabilizing HIF-1α and activating the Wnt/β-catenin signaling pathwayHIF-1α expression knockdown disrupted roxadustat-promoted osteoblast differentiation and matrix mineralization. A ALP staining at day 7. B Alizarin Red S staining at day 14. Data are presented as the mean ± SD of three independent experiments; *P < 0.05, **P < 0.01, compared with the siNC group; ##P < 0.01, compared with the siHIF-1α + roxadustat group. Roxadustat concentration: 5 μMBack to article page