Skip to main content
Fig. 10 | Journal of Orthopaedic Surgery and Research

Fig. 10

From: Roxadustat promotes osteoblast differentiation and prevents estrogen deficiency-induced bone loss by stabilizing HIF-1α and activating the Wnt/β-catenin signaling pathway

Fig. 10

Effects of roxadustat on dynamic parameters of trabecular bone histomorphometry. A Representative images of TRAP staining of the left tibiae to identify osteoclasts. The arrows point to osteoclasts. Scale bars: 200 μm. B The calculation results for Oc.S/BS and N.Oc/BS. C HE staining images of the left tibiae to observe osteoblasts. The arrows point to osteoblasts. Scale bars: 100 μm. D The calculation results for Ob.S/BS and N.Ob/BS. E The calculation results for MAR and BFR/BS. Data are presented as the mean ± SD; n = 8 per group; *P < 0.05, **P < 0.01, compared with the sham group; #P < 0.05, ##P < 0.01, compared with the OVX group. Oc.S/BS or Ob.S/BS: osteoclast or osteoblast surface per millimeter bone perimeter. N.Oc/BS or N.Ob/BS: osteoclast or osteoblast number per millimeter bone perimeter. MAR = double-labeled width/labeled time interval. BFR/BS = (double-labeled surface + single-labeled surface/2)*MAR/trabecular perimeter

Back to article page

Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X