Table 2 The information of others sarcoma
From: MicroRNA-143 expression inhibits the growth and the invasion of osteosarcoma
Author | disease | Genes/proteins affected | Functions |
|---|---|---|---|
Kapodistrias [23] | Liposarcoma | – | miR-155, miR-21, miR-143, miR-145 and miR-451 that are implicated in liposarcoma, as novel formalin-fixed paraffin-embedded tissue biomarkers |
Urdinez [22] | Chondrosarcoma | miR-143/145 ┤ FSCN1 | miR 143/145/FSCN1 as important players in chondrosarcoma progression. Restoration of miR143/145 levels in tumors or direct FSCN1 targeting may hold potential as novel therapeutic approaches to chondrosarcoma |
Ugras [20] | Liposarcoma | miR-143-3p ┤ BCL2, TOP2A, PRC1, and PLK1 | Restoring miR-143 expression in dedifferentiated liposarcoma cells inhibited proliferation, induced apoptosis, and decreased expression of BCL2, TOP2A, PRC1, and PLK1. The downregulation of PRC1 and its docking partner PLK1 suggests that miR-143 inhibits cytokinesis in these cells. In support of this idea, treatment with a PLK1 inhibitor potently induced G2/M growth arrest and apoptosis in liposarcoma cells |
De Vito [21] | Ewing Sarcoma | TARBP2 | The miRNA profile of Ewing sarcoma family tumor cancer stem cells is the result of reversible disruption of TARBP2-dependent miRNA maturation. Restoration of TARBP2 activity and systemic delivery of synthetic forms of either of two of its targets, miRNA-143 or miRNA-145, inhibited Ewing sarcoma family tumor cancer stem cells clonogenicity and tumor growth in vivo |